Study on Synthesis of Fraistone Catalyzed by Noibic Acid

Fraistone was synthesized from ethyl acetoacetate and 1,2 propanediol using noibic acid as catalyst Various factors that effect the condensation yield were investigated The optimum reaction conditions are as follows:ethyl acetoacetate:1,2 propanediol is 1 0 mol∶1 5 mol;the mass fraction of catalyst is 1 5%;the volume fraction of agent to remove water is 42 2% of the volume of reaction mixtare;reaction temperature is reflux temperature,reaction time is 2 5 h The yield is above 83 4 %.