Mechanism of Xiaochaihu Decoction Inhibiting Proliferation of H22 Mice Liver Cancer Cells

Objective: To investigate the effect of Xiaochaihu Decoction improving the immune function and inhibiting the tumor proliferation of H22 hepatoma. Methods: 30 mice were preferred as the research objects H22 hepatoma mice models were established with intraperitoneal injection of H22 hepatoma. All mice were randomly divided into control group,low-dose,middle dose and high dose Xiaochaihu Decoction groups,5-FU group and H22 hepatoma model groups,5 mice of each group. The group weight,inhibition rate,serum tumor markers and the levels of inflammatory factors of each group were compared. Results: ①Weight Analysis: the weight of mice of Xiaochaihu high-dose group was not statistically significant than that of the normal control group( P 0. 05). The weight of mice of 5-FU group was significantly decreased than that of the control group( P 0. 05). ②The rate of inhibition: the rate of inhibition of 5-FU was higher than that of the other treatment groups,while Xiaochaihu medium and high dose groups inhibition was higher than that of the low dose group,and the difference was statistically significant( P 0. 05). ③Serum tumor markers:the middle and high-dose Xiaochaihu Decoction groups serum alpha-fetoprotein( AFP) and carcinoembryonic antigen( CEA) were lower than that of the low-dose group and 5-FU group,whereas ferritin( SF) was higher than that of the low-dose group and the 5-FU group. ④Levels of inflammatory factors: Xiaochaihu Decoction high-dose group's NK cell activity,IL-2 and INF-γ levels were significantly higher than that of the low-dose group and 5-FU group,while TNF-α levels were significantly lower than that of the low-dose group and 5-FU group,and the difference was statistically significant( P 0. 05). Conclusion: Xiaochaihu Decoction certain dose can effectively inhibit the growth of cancer cells in mice H22 liver cancer,and can improve the body's immunity levels.