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2004•Tuberculosis & respiratory diseasesOpen access

The Effect of Interferon-γ on Bleomycin Induced Pulmonary Fibrosis in the Rat

Hyoung Kyu Yoon, Yong Hyun Kim, Soon Seog Kwon, Young Kyoon Kim, Kwan Hyung Kim, Hwa Sik Moon, Sung Hak Park, Jeong Sup Song

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Abstract

Objectives : The matrix metalloproteinases (MMPs) that participate in the extracellular matrix metabolism play a important role in the progression of pulmonary fibrosis.The effects of the MMPs are regulated by several factors including Th-1 cytokines, interferon-γ (IFN-γ).Up to now, IFN-γ is known to inhibit pulmonary fibrosis, but little is known regarding the exact effect of IFN-γ on the regulation of the MMPs.This study investigated the effects of interferon-γ on the pulmonary fibrosis and the expression of the lung MMP-2,-9, TIMP-1,-2, and Th-2 cytokines in aa rat model of bleomycin induced pulmonary fibrosis.Materials and methods : Male, specific pathogen-free Sprague-Dawley rats were subjected to an intratracheal bleomycin instillation.The rats were randomized to a saline control, a bleomycin treated, and a bleomycin+IFN-γ treated group.

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Objectives : The matrix metalloproteinases (MMPs) that participate in the extracellular matrix metabolism play a important role in the progression of pulmonary fibrosis.The effects of the MMPs are regulated by several factors including Th-1 cytokines, interferon-γ (IFN-γ).Up to now, IFN-γ is known to inhibit pulmonary fibrosis, but little is known regarding the exact effect of IFN-γ on the regulation of the MMPs.This study investigated the effects of interferon-γ on the pulmonary fibrosis and the expression of the lung MMP-2,-9, TIMP-1,-2, and Th-2 cytokines in aa rat model of bleomycin induced pulmonary fibrosis.Materials and methods : Male, specific pathogen-free Sprague-Dawley rats were subjected to an intratracheal bleomycin instillation.The rats were randomized to a saline control, a bleomycin treated, and a bleomycin+IFN-γ treated group.

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Available abstract

Objectives : The matrix metalloproteinases (MMPs) that participate in the extracellular matrix metabolism play a important role in the progression of pulmonary fibrosis.The effects of the MMPs are regulated by several factors including Th-1 cytokines, interferon-γ (IFN-γ).Up to now, IFN-γ is known to inhibit pulmonary fibrosis, but little is known regarding the exact effect of IFN-γ on the regulation of the MMPs.This study investigated the effects of interferon-γ on the pulmonary fibrosis and the expression of the lung MMP-2,-9, TIMP-1,-2, and Th-2 cytokines in aa rat model of bleomycin induced pulmonary fibrosis.Materials and methods : Male, specific pathogen-free Sprague-Dawley rats were subjected to an intratracheal bleomycin instillation.The rats were randomized to a saline control, a bleomycin treated, and a bleomycin+IFN-γ treated group.

Key concepts: Bleomycin, Pulmonary fibrosis, Fibrosis, Zymography, Hydroxyproline, Medicine, Matrix metalloproteinase, Lung

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