Expression and clinical significance of COX-2,Survivin in breast benign lesion and breast carcinoma

Objective:To investigate the relationship between the expression of cyclooxygenase-2(COX-2) and survivin in breast benign lesion,ductal carcinoma in situ and invasive breast carcinoma and their clinical significances.Methods:Sixty cases of breast benign lesion,60 cases of ductal carcinoma in situ and 60 cases of in invasive breast carcinoma were detected by of the immunohistochemical staining.Results:The positive rate of COX-2 were 50.00%(30/60) in breast benign lesion,76.67%(46/60) in breast ductal carcinoma in situ and 81.67%(49/60) in breast invasive ductal carcinoma,the difference showed statistically significance(P0.05).In breast benign lesion the positive rate of survivin was 41.67%(25/60),in breast ductal carcinoma in situ it was 60.00%(36/60),in breast invasive ductal carcinoma the positive rate of survivin was 70.00%(42/60),which were significantly different(P0.05).COX-2 expression was not associated with patient's age,tumor size,PR state,menopause or not(P0.05),but it was correlated with patient's lymph node metastasis,clinical stages,estrogen receptor positive(P0.05).Survivin expression was not associated with patient's age,tumor size,ER state,PR state,menopause or not(P0.05),but it was correlated with patient's lymphnode metastasis,clinical stages(P0.05).COX-2 expression was positive relation to survivin expression(r=0.33,P0.05).Conclusion:COX-2 and survivin might play an important role in the carcinogenesis and progression in breast carcinoma.A positive correlation between expression of COX-2 and survivin were observed in breast carcinoma,COX-2 has coordinated action with survivin in the carcinogenesis and progression in breast carcinoma.