Expression and correlation of p27,survivin in breast carcinoma

Objective: To study the expression and correlation p27,survivin in breast carcinomas.Methods: The expression of p27,survivin were studied in 48 cases of breast carcinomas by immumohistochemical technology and 29 cases of benign lesions served as control.Result:(1) Positive rates of p27,survivin in breast benign lesions were 79.3%(23/29),24.1%(7/29)respectively.Positive rates of p27,survivin in breast carcinomas were 42%(20/48),72.9%(35/48) respectively.Positive rates of p27,survivin in breast benign lesions and in breast carcinomas had significance of statistics(P0.01).(2) There was a negative correlation between the expression of p27 and survivin in breast carcinomas(P0.05).(3) The expression of p27 in breast carcinomas did not correlate with age,nation of patients(P0.05).But,Expression of p27 in breast carcinomas was associated with hitological grading(P0.01).The expression of survivin in breast carcinomas did not correlate with age,nation of patients,histological grading(P(0.05)).Conclusions:(1) Abnormal expression of p27,survivin may play an important role in initiation and development of breast carcinomas.(2) p27,survivin may interact with each other in breast carcinomas.(3) Abnormal expression of p27,survivin may contribute to conversion between breast benign lesions and breast carcinomas. They can be used to identify benign and malignant breast disease.There is some significance of prediction,as malignant change of breast benign diseases.