The clinical study of CT-guided percutaneous conformal argon-helium cryoablation for non-small cell lung carcinoma

Objective To investigate the safety,efficacy and clinical value of CT-guided percutaneous conformal cryoablation for non-small cell lung carcinoma.Methods One hundred and seventy two patients with non-small cell lung carcinoma were treated by CT-guided pereutaneous conformal cryoablation.CT scan was performed to monitor the dynamic change at different stage after cryosurgery.The Karnofsky score,tumor markers,treatment response and survival rate were tested to evaluate the efficacy of the surgery.Results All patients underwent cryoablation,the immediate CT scan after cryosurgery showed iceball formation.About 1 month later,CT images showed obviously decrease on density and tumor size,according to RECIST criteria,the remission rate(PR+CR)was 63.9%.PET/CT was performed on 6 cases of patients,and showed lower radioactivity.The remission rate after 3 and 6 months was 61.4% and 54.5% respectively.The Karnofsky score in one week after cryosurgery improved from 82.26±11.73 to 84.87±10.71.The tumor markers were tested pre and post cryoperation.About 83.06% decreased in one week to a greater or lesser extent.The medial survival time was 11.97 months,1 and 2 years suivival rate was 41.71% and 27.58% respectively.The complication was minimal,8 cases had hemoptysis,56 cases streak of blood in expectoration,36 cases pneumothorax and of 5 cases on late-onset type,these gases completely absorbed after drainage.Conclusions CT-guided percutaneous conformal cryoablation,with minal procedure associated positive curative effect,is a promising treatment for non-small-cell lung carcinoma.