Experimental Treatment of Deduhonghua-7 Powder on CCl_4 Induced Hepatic Fibrosis

Objective:To observe the treatment of Deduhonghua-7 Powder on rat with carbon tetrachloride(CCl4) induced hepatic fibrosis.Method: Rats were randomly divided into normal control group,model group,Colchicine group and Deduhonghua-7 powder group.Except the normal control group,other groups were caused hepatic fibrosis by ip 30% CCl4 solution of olive oil.Modeling the same time,the rats in Deduhonghua-7 powder group and Colchicine group were ig 0.62 g·kg-1 and 0.4 mg·kg-1 each day of Deduhonghua-7 powder and Colchine respectively,continued for 7 days.Liver indexes,liver function,fibrosis four projects were observed,pathological changes in liver tissues were evaluated by HE,Gomori,Masson stainings.Result: Comparing with normal control group,aspartate transaminase(AST),alanine transpeptidase(ALT),alkaline phosphatase(ALP),total protein(TP),total bilirubin(TBIL),liver indexes,fibrosis four projects of serum and liver tissues homogenates were significantly increased,albumin(Alb),and bodyweight were decreased in the model group(P0.05).Comparing with model group,in the Deduhonghua-7 Powder group,AST,ALT,ALP,liver indexes,liver tissues homogenates Hyp,serum and liver tissues fibrosis four projects were significantly decreased,Alb was increased;and in the Colchine group,ALT,AST,ALP,BIL were decreased,liver tissues hyaluronic acid(HA) was increased,IV was decreased(P0.05).Comparing with Colchine group,Deduhonghua-7 Powder group's Alb was increased,serum HA,LN contents were decreased,liver tissues HA,LN,IV-C,Hyp contents were decreased(P0.05).Conclusion: Deduhonghua-7 Powder showed good effect on reducing enzyme,protecting liver and anti-fibrosis for liver.