Distribution and antifungi resistance of 508 strains of Candida isolated from clinic

Objective To investigate the distribution and drug resistance of clinical isolated Candida,so as to provide basis for clinical treatment.Methods Fungi culture was performed with routine method,strains of Candida were identified with VITEK-32 Automicrobic System,drug sensitive test of Candida was tested by microdilution method.Results Among 508 strains,Candida albicans accounted for 369 strains(72.64%),Candida tropicalis 48 strains(9.45%),Candida famata 26 strains(5.12%).93.22%(344/369) of Candida albicans and 89.58%(43/48) were isolated from respiratory tract samples,the isolation rate of Candida from respiratory tract was obviously higher than that from the other clinical samples(x2=644.26,P0.01).The MIC90 of Candida albicans to fluorocytosine,amphotericin B,fluconazole,itraconazole and voriconazole was ≤16 mg/L,≤0.5 mg/L,≤1 mg/L,≤0.25 mg/L and ≤0.06 mg/L respectively,antifungi-resistant rate were 1.12%(3/269)～ 10.78%(29/269).Conclusion The main isolated Candida in this hospital is Candida albicans,most of which were isolated from respiratory samples.The resistance of Candida albicans to antifungi drug are relatively low,the monitor of drug-resistance of Candida is still necessary.