The Efficacy and Sofery of Topiram in Patients with Epilepsy

Objective:To observe the clinical efficacy and adverse reaction(AR)of topiramate(TPM)in treatment of epilepsy, and to explore the optimal mode of administration.Methods:One hundred and ninety-nine patients with epilepsy were divided into two groups according to different starting dose and the rate of increasing dosage,Group A (102 cases),the starting dose of TPM was 25 mg/d and the increasing dos-age per week was 25 mg until 200 mg/d was reached and then maintained for 12 wks;Group B(97 cases),the starting dose of TPM was 50mg/d and the increasing dosage per week was 50 mg until 200 mg// d was reached and then maintained for 12 weeks.Results:The total effective rate and controlrate in Group A were 77.7% and 42.1%;whereas those in Group B were 76.2 and 40.2,respectively.Significant difference was found between both groups(P＞0.05).More ARs were observed in Group B as compared with Group A (P＜0.05).Conclusion:A small starting dose fol- lowed by slowly increasing dosage is recommended to patients with lower seizure frequency.