Comparative Study of Transhepatic Artery Interventional Thermochemotherapy and Embolism Combined with Radiofrequency Ablation in the Treatment for Hepatic Carcinoma

Objective To assess the therapeutic effect of transhepatic artery interventional thermochemotherapy and embolism combined with radiofrequency ablation in treating hepatic carcinoma.Methods 80 cases with stageⅠ-Ⅱhepatic carcinoma were retrospectively analyzed.In group A(thermochemotherapy and embolization + RFA group,n=36),the catheter was inserted into the intrahepatic tumor feeding artery using seldinger technique with Gemcitabine 1000mg dissolved in 1200 ml normal saline.The perfusion temperature 51℃ and flow rate of 0.8- 1.0 ml/s was set and thermochemotherapy was given,then Gemcitabine 200mg + Carboplatin 200mg + lipiodol were used for chemoembolization treatment.In group B(thermochemotherapy and embolization groups,n=44),the program for thermochemotherapy and embolization was same to group A.The treatment was repeated once every four weeks as a cycle.After the completion of two cycles of treatment and then an interval of two weeks,RFA under general anesthesia was used to treat the primary lesions in group A.Consecutive four cycles of treatment were used in group B.After treatment,Efficiency was evaluated with images according to mRECIST standard.KPS,short term effect,AFP negative conversion rate,year survival rate,median survival time were compared between two groups.Results The KPS score improvement,AFP negative conversion rate and the overall response rate in Group A were better than those in group B.There were significant difference between the two groups(P0.05).In group A,the 1,2,3 year Survival rate was 97%,92%,78%,median survival time(MST)was 43 months.In group B,the 1,2,3 year Survival rate was 80%,70%,36%,median survival time(MST)was 29 months.There were significant difference between two groups(P0.05).Conclusion The treatment effect of hepatic carcinoma can be further improved by transhepatic artery interventional thermochemotherapy and embolism combined with radiofrequency ablation.