The Effect of Mechanism ICC Excessive Activity by Stem Cell Factor in Rats with IBS

The c-Kit as the identification of ICC,its ligand-stem cell factor(SCF) can secrete large amounts of c-kit kinase stimulate mast cells to hyperplasia.The development and survival of ICC use the same cell signal transduction pathways;therefore,SCF is the most important cytokine to the start of c-kit kinase.Our recently studies show that when SCF excessive activated,the abnormal discharge of ICC increased,then the dorsal commissural nucleus(DCN) that control the movement of left colon produce significant changes in electric activities,which indicates SCF plays an important role in pathogenesis of IBS.From that point,In order to explore the excessive activated SCF leads to abnormal discharge of ICC in the role and pathogenesis of IBS,this study was designed to in vivo and in vitro;using the method of morphology,electrophysiology,molecular biology and seropharmacology,provide new ideas for the development of new drugs.