Effect of Shengeyifei Capsule on Inflammatory Mediators in Rat with Chronic Obstructive Pulmonary Disearse

Objective To observe the effect of Shengeyifei capsule on the inflammatory mediators in the airway and the pathology of the airway in the rat with chronic obstructive pulmonary diserse (COPD). Methods 60 SD rats were divided randomly into normal group, COPD model group, Jinshuibao control group and Shengeyifei groups. The COPD model was established by smoking and infusing lipopoly- saccharide (LPS). The level of interleukin-8 (IL-8) and tumor necrosis factor α (TNF-α) in bronchoalveolar lavage fluid (BALF) were measured and the pathology of the airway and lung tissue was observed after treatment on the rats. Result The levels of IL-8 and TNF-α in Shengeyifei groups were lower than in COPD model group (P 0.01), the pathological changes were also lessen in Shengeyifei groups. Conclusion Shengeyifei capsule has inhibitory effect on inflammation in the airway with COPD.