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2007•China Practical MedicineRequires access

Significance of Survivin and Survivin mRNA in breast carcinoma

Ying Huang

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Abstract

Objective To study the relationship between Survivin and breast carcinoma by combining assays of Survivin and Survivin mRNA in breast tissue.Methods Apoptosis Index(AI)was evaluated by TUMEL method,the expression of Survivin and Survivin mRNA were detected by immunohistochemistry and In Situ Hybridization in 48 breast carcinoma cases and those tissues beside carcinoma.Results The higher level of Survivin and Survivin mRNA were found in breast carcinoma compared with tissues beside carcinoma(P=0.001 6,P=0.000 0).There was positive relationship between the expression of Survivin,Survivin mRNA and AI(r=0.533,P=0.005;r=0.455,P=0.003).Conclusion Survivin may participate in proceeding of breast carcinoma,and it is suggested that combined detection of Survivin and Survivin mRNA may have important referent significance on the differentiation of benign and malignant breast tissue.

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What this paper is about

Objective To study the relationship between Survivin and breast carcinoma by combining assays of Survivin and Survivin mRNA in breast tissue.Methods Apoptosis Index(AI)was evaluated by TUMEL method,the expression of Survivin and Survivin mRNA were detected by immunohistochemistry and In Situ Hybridization in 48 breast carcinoma cases and those tissues beside carcinoma.Results The higher level of Survivin and Survivin mRNA were found in breast carcinoma compared with tissues beside carcinoma(P=0.001 6,P=0.000 0).There was positive relationship between the expression of Survivin,Survivin mRNA and AI(r=0.533,P=0.005;r=0.455,P=0.003).Conclusion Survivin may participate in proceeding of breast carcinoma,and it is suggested that combined detection of Survivin and Survivin mRNA may have important referent significance on the differentiation of benign and malignant breast tissue.

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Available abstract

Objective To study the relationship between Survivin and breast carcinoma by combining assays of Survivin and Survivin mRNA in breast tissue.Methods Apoptosis Index(AI)was evaluated by TUMEL method,the expression of Survivin and Survivin mRNA were detected by immunohistochemistry and In Situ Hybridization in 48 breast carcinoma cases and those tissues beside carcinoma.Results The higher level of Survivin and Survivin mRNA were found in breast carcinoma compared with tissues beside carcinoma(P=0.001 6,P=0.000 0).There was positive relationship between the expression of Survivin,Survivin mRNA and AI(r=0.533,P=0.005;r=0.455,P=0.003).Conclusion Survivin may participate in proceeding of breast carcinoma,and it is suggested that combined detection of Survivin and Survivin mRNA may have important referent significance on the differentiation of benign and malignant breast tissue.

Key concepts: Survivin, Medicine, Breast carcinoma, Messenger RNA, Immunohistochemistry, Carcinoma, In situ hybridization, Cancer research

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