Nosocomial Infection and Resistance of Coagulase Negative Staphylococcus

OBJECTIVE To study the distribution and drug resistance of coagulase negative Staphylococcus(CNS)that leads to nosocomial infection.METHODS Nosocomial CNS was identified and then drug resistance test was performed by K-B method.Nitrocefin method and the Congo red method were utilized to detect β-lactamase and the slime,respectively.RESULTS Of all 162 CNS strains isolated,there were 102 strains of MRCNS and 60 strains of MSCNS including 83 S.epidermidis strains,accounting for 51.2%.Among all the MRCNS and MSCNS strains above,the positive rates of the β-lactamase were 100.0% and 5.0%,respectively,and the positive rates of the slime were 17.6% and 1.7%,respectively.The resistance rates of MRCNS to 12 types of antibiotics were higher than those of MSCNS(P0.01).All CNS was sensitive to vancomycin.CONCLUSIONS CNS is increasingly playing a significant role in nosocomial infection.The elevation of drug resistance of CNS has relations with β-lactamase and the slime.To control this kind of nosocomial infection,it is critically important to monitor the antimicriobial resistance of CNS.