Distribution and drug-resistance of 408 strains coagulase negative stapylococcuse

Objective To study the distribution and drug resistance of coagluase negative stapylococcuse(CNS).MethodsThe methicillin-resistance and grug-resistance of the CNS strains isolated from the clinical specimens of the inpatient in our hospital between 2007 to 2009 were tested.ResultsOf all 408 CNS strains of MSCNS,there were 152 S.epidermidis strains,accounting for 37.26%(152/408),and 286 MRCNS strains in which 280 producing β-lactamase(The positive rate of β-lactamase was 97.9%),and 122 MSCNS strains(79.90%)including 17 strains which producing β-lactamase(the rate was 13.93%).Comparing the two,the difference was significant.(P0.01).The resistance rate of MRCNS to 13 types of antibiotics were higher than those of MSCNS(P0.01).All CNS was sensitive vancomycin.ConclusionCNS is increasingly playing a significant role in nosocomial infection.The increase of drug resistance of CNS has relation with β-lactamasse;the clinic should monitor the etiology and resistance of CNS,use the drug reasonably.