Clinical study of target fibrinogen level treated by Batroxobin in patients with acute cerebral infarction

Objective To explore the dynamical change of fibrinogen levels treated by Batroxobin in patients with acute cerebral infarction in order to approach a target level of defibrinogen therapy.Methods Fifty patients with acute cerebral infarction were randomly divided into routine dose group (20 cases) and high dose group (30 cases). The patients in routine dose group and high dose group were treated intravenously with Batroxobin 10 BU, 5 BU, 5 BU and 10 BU, 10 BU,5 BU, 5 BU in every other day, respectively. The routine function of blood coagulation was examined before drug administration, at 8~12 h after first administration and at 4~6 h before afterward administrations. Brain CT or MRI scan was performed at 2~3 weeks after the onset of disease, and the grading of Barthel index was evaluated at 3 months after the treatment.Results The blood level of fibrinogen dropped obviously at 12 h after the first administration of Batroxobin, went up rapidly before the 2nd administration, and then kept stability in the course of treatment. The prolong of APTT and/ or PT in low fibrinogen level group (40～69 mg/dl) was more than in high fibrinogen level group (130 mg/dl). Conclusions The fibrinogen level may reduce to 40～130 mg/dl treated with Batroxobin in patients with acute cerebral infarct, but whether it could be regarded as a target level need more studies.