The expression and clinical significance of IGF-II and PCNA in Leiomyoma of Uterus

【Objective】 To determine the expression of insulin-like growth factor-Ⅱ(IGF-Ⅱ) and proliferating cell nuclear antigen(PCNA) in the uterine leiomyoma,and to investigate the role of IGF-Ⅱand PCNA in the pathogenesis of uterine leiomyoma.【Methods】 Immunohistoehemical method was employed to detect the expression of IGF-Ⅱin the uterine leiomyoma,the tissues beside hysteromyoma and the normal myometrium,the same methods to detect the expression of PCNA.【Results】 ①The expression of IGF-Ⅱ: The positive expression rates in the uterine leiomyoma tissues beside hysteromyoma and the normal myometrium were 60%,16.67%,10%.There were significant differences between the uterine leiomyoma,the tissues beside hysteromyoma and the normal myometrium(P =0.000).② The expression of PCNA: The positive expression rates in the uterine leiomyoma,the tissues beside hysteromyoma and the normal myometrium were 83.3%,26.7%,20%.There were significant differences between the uterine leiomyoma,the tissues beside hysteromyoma and the normal myometrium(P =0.000).③The expression of IGF-Ⅱ and PCNA was positive correlation(rs =0.55,P 0.05).【Conclusion】 ①The high expression of IGF-Ⅱand PCNA in uterine leiomyoma indicates IGF-Ⅱand PCNA are related with the development of the uterine leiomyoma.②The positive correlation between IGF-Ⅱand PCNA suggest that IGF-Ⅱrelated with cell proliferation and this relationship maybe one of the etiology of the Uterine leiomyoma.