2004•Parenteral & Enteral NutritionRequires access
The clinical application of immune enteral nutrition support to malignant obstructive jaundice patients after operation
Qing Hu
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Abstract
Objective: Patients with malignant obstructive jaundice (OJ) often have malnutrition associated with increased perioperative morbidity. This study was designed to investigate the clinical effects of immune enteral nutrition in these patients. Methods: A series of 40 malignant OJ patients were investigated prospectively. These patients were equally divided into standard enteral nutrition group and immune enteral nutrition group randomly. Two groups were compatible in ages, genders and operation modes. The standard enteral nutrition agent was used to standard enteral nutrition group and supportan to immune enteral group with the same total energy of 30 kcal/(kg·d) after operation. The enteral nutrition support time was not less than ten days. Plasma albumin, PAB, ALT, AST, the percentage of T lymph cell subgroups and the concentration of serum IL 6 were detected 2 days before operation, the 4 th day and the 14 th day after operation. Results: ① In the 14 th day after operation, the level of ALB in immune enteral group was higher than that in standard enteral nutrition group ( P 0.05). ② The level of ALT, AST in immune enteral nutrition group did not declined more obviously than that in standard enteral nutrition group. ③The ratio of CD4/CD8 in immune enteral nutrition group was higher than that in standard enteral nutrition group( P 0.01). The ratio of CD4/CD8 in the 14 th day after operation increased in immune enteral nutrition group ( P 0.05), and did not change in standard enteral nutrition group. ④ The level of serum IL 6 in immune enteral nutrition group was lower than that in standard enteral nutrition group( P 0.05). Conclusions: Immune enteral nutrition is a safe and effective support method to malignant OJ patients after operation,and can improve the nutrition state of patients, enhance the function of immune system and regulate turbulent inflammatory response more obviously than standard enteral nutrition.