Influence of modified Tongqiao Huoxue poultice on hemodynamics,ET and NO in rats of blood Stasis syndrome

Objective To study the influence of modified Tongqiao Huoxue poultice on hemodynamics,ET and NO in-rats model of blood stasis syndrome. Methods Sprague Dawley rats were divided into four groups in random: control group,blood stasis group and group of modified Tongqiao Huoxue poultice. All groups were detected for whole blood viscosity,plasma viscosity( PV),red blood cell aggregation index,endothelin and NO. Results 1. The values of blood viscosity and PV at different shear rates were significantly lower in group of modified Tongqiao Huoxue poultice than in-blood stasis group( P 0. 05). 2. Group of modified Tongqiao Huoxue poultice had a significantly higher RBC deformation index and a significantly lower RBC aggregation index than blood stasis group( P 0. 05). 3. Compared with blood stasis group,group of modified Tongqiao Huoxue poultice significantly decreased the level of serum endothelin( P 0. 05),and increased the level of NO( P 0. 05). Conclusions Modified Tongqiao Huoxue poultice can improve hemodynamics,ET and NO in rats model of blood stasis syndrome,therefore,it has the effect of activating blood and resolving stasis and is effective for blood stasis syndrome.