Impacts of Busuishenxue Granules on HGF mRNA Expression of Bone Marrow Mononuclear Cell in Patients with Chronic Aplastic Anemia

Objective To discuss the impacts of Busuishengxue granules on HGF mRNA expression in bone marrow mononuclear cell(BMMC) in chronic aplastic anemia(CAA). Methods 60 CAA patients were randomly divided into treatment group and control group,with the former given Busuishenxue Granules and the latter given CAA Zaizhangshengxue tablets.Reverse transcription-polymerase chain reaction(RT-PCR) method was adopted to determine the changes of expression of BMMC HGF mRNA before and after treatment in CAA. Results Patients from the two groups were cured generally with remission rate 73.33% and 57.14% respectively.Treatment group was superior to control group 57.14% in effectiveness(P0.05).The expressions of BMMC HGF mRNA in CAA patients were higher than that in normal group.After treatment,the expressions of them were all decreased in both groups to different degrees.But the downgrade degree of the expressions induced by Busuishengxue granules was superior to that induced by Zaizhangshengxue tablets(P0.05). Conclusion The expression of BMMA HGF mRNA is abnormal in CAA patients.Busuishengxue granules improve hematopoietic function of bone marrow in CAA patients and accelerate the recovery of hematopoietie function.