Treatment of CIK cells for advanced malignant tumor patients curative effect research

Objective: To observe autologous CIK cells to immunotherapy in patients with advanced malignant tumor,quality of life and related index changes.Methods: The peripheral blood of patients with isolated mononuclear cells joined IFN-y,anti CD3 monoclonal antibody,cytokines such as IL-2,CIK cells expanded in four transfusion patients,and quality of life,adverse reaction and related indexes were observed in patients.Results: In 38 patients receiving CIK treatment for pain relief,weight gain and sleep improved significantly,side effects were slight,the difference was statistically significant(P 0.05),and efficiency(CR+PR+MR) of 66%,tumor markers in peripheral blood of patients decreased,CD3,CD4 T and NK cell ratio were significantly increased(P0.05).Conclusion: Autologous CIK cell adoptive immunity therapy can significantly increase the cancer patients' quality of life,improve clinical symptoms and the immune function of patients with advanced cancer patients.