A Contrastive study of gliomas treated with postoperative radiotherapy with or without chemotherapy

Objective To analyze the clinical efficacy of malignant glioma treated by combined chemotherapy and radiotherapy after surgery. Methods Ninety- two patients with glioma were selected who had received treatment in our hospital from January 2009 to June 2010. Of them,64 patients received grossly total resection,28 patients subtotal resection and all cases were randomly divided into two groups. Group A received chemotherapy plus radiotherapy after resection,while group B underwent radiotherapy alone. Both groups were compared for short- term and long- term efficacy,and adverse reactions. Results The short- term effective rate of A group was 67. 4% ~ 71. 7%,which was higher than that of B group(41. 3% ~47. 8%). The 1-,2-,and 3- year survival rate of group A were 82. 6%,50. 0% and 32. 6% respectively,which were higher than those of group B. There was no significant difference in adverse reactions between the two groupsConclusions Combined chemotherapy and radiotherapy is effective for malignant glioma with less adverse reactions,which is worthy of promotion.