The expression of Clusterin protein in breast carcinoma and its clinical significance

Objective:To investigate the protein expression of Clusterin in breast cancer and its clinical significance.Methods: Clusterin expression were examined by immunohistochemical staining method in 60 cases with breast cancer,10 cases with benign pathological changes and 10 cases with normal breast tissues.Results:The positive rates of Clusterin in normal breast tissues,benign pathological changes and breast cancer tissues were 0%,10% and 78.33%,respectively.The expression of Clusterin in breast cancer was much higher than that in nor,hal breast tissues(P0.05)and benign pathological cbanges(P0.05).The expression of Clusterin in breast cancer tissues was closely related to histological type(P0.05)and lymph node metastasis(P0.05).but no correlated to the age,tumor size and clinical stage.There was a negative correlation between ER,PR and Clusterin.There was no correlation between C-erbB-2 and Clusterin.There was a positive correlation between p53,Ki67 and Clusterin.Conclusion:Clusterin may play an important role in the biological characteristics of breast cancer by the antiapoptosis pathway.It may be used as a potential therapeutic target for breast cancer.