The effects of quadruple regimens for the treatment on helicobacter pylori infection

Objective To study the effect of quadruple regimens for two weeks on the treatment of peptic ulcer and chronic gastritis in combination with H.Pylori infection.Methods Patients with gastroendoscopy and 14C-urea breath testing(14C-UBT)confirmed helicobacter pylori infection were administered with esomeprazole 20 mg twice a day.And Weisanlian twice a day(per os)for two weeks.14C-UBT examination was carried after cessation of the treatment.Results Among the 300 patients,138 cases were with peptic ulcer and 162 cases were with chronic gastritis.H.pylori status was assessed by the 14C-UBT in 281 patients.H.pylori eradication rate was 91.1%(256/281).There was no statistical difference of H.pylori eradication rate between the peptic ulcer and chronic gastritis(92.3%vs 90%).Conclusion The efficacy of quadruple therapy for H.Pylori infection is sure with low cost and no significant side effects.It is a ideal method for H.pylori eradication.