Study the effect of Xianji Huaban capsules on mast cell degranulation and histamine release

[Objective] To research the mechanism of Xianji Huaban capsules against hypersensitivity reaction,providing the foundation for later experiment and clinical treatment of allergic purpura.[Methods] By preparing the sensitization of rats and anti-egg protein in serum and giving different concentrations,we measured the skin blue spot diameter through the experimental of passive cutaneous ana phylaxis(PCA);then,we measured the degranulation percentage and the level of histamine release through the skull periosteum mast cells degranulation test and the mast cells release histamine test in rats.[Results] Xianji Huaban capsules could make the skin blue spot diameter smaller,decrease mast cells degranulation percentage,and reduce the release of histamine in a concentration dependent man ner.[Conclusion] Xianji Huaban capsules have the effect against hypersensitivity reaction by inhibiting PCA,mast cells degranulation and histamine releasing.