2006•The Chinese Journal of DermatovenereologyRequires access

An Experminential Study of Desensitiger Formula in Inhibiting the Degranulation of Mast Cells

Xiaoping Liu

Abstract

Objective To study the effects of desensitiger formula in inhibiting the degranulation of mast cells.Methods Mastocyte degranulation test,the release of histamine and the expression of 5-HT in peritoneal mast cells were performed in the cell models hypersensitized by rat anti-ovalbumin antiserum.Results Desensitiger formula 1.4 g/mL and 2.8 g/mL significantly inhibit the degranulation of mast cells,decrease the release of histamine and 5-HT.Conclusion Desensitiger formula may inhibit the degranulation of mast cells,it has the effect of anti-hypersensitivity typeⅠ.

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Key concepts: Degranulation, Histamine, Compound 48/80, Mast (botany), Ovalbumin, Mast cell, Chemistry, Histamine H4 receptor