The Study of Therapeutic Efficacy and Safety of Felodipine in the Therapy for Renal Hypertension

Objective To study the therapeutic efficacy and safety of felodipine in the therapy for renal hypertension.Methods One hundred fourty two patients that remal hypertension were diagnosed were randomly allocated into two groups to be treated for 8 weeks:felodipine treated group(83 cases)and Fosinpril divided group(59 cases).The blood pressure,renal function,urea protein,heart rate,administration status and adverse reactions of the patients were observed during treating time.Rusults After 8 weeks of treatment,the blood pressure in felodipine group and Fosinpril group were reduced by(25.63±11.80)/(12.18±9.07)mmHg,(21.87±10.72)/(11.93±8.98)mmHg respectively,which were not significant(P 0.05).The total effective rate in felodipine group and Fosinpril group were 91.45%(76/83)and 89.66%(53/59)respectively,which were not significant(P 0.05).The total adverse event incidences in felodipine group and Fosinpril group were 9.64%,11.86%respectively,which were not significant(P 0.05).However,the cough incidence in Fosinpril group(8.47%)was significantly higher than that in the felodipine group(0.00%)(P 0.01).Conclusion Felodipine has a better efficacy and is safe in the therapy for renal hypertension.