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Relationship Blood-Lipid to Serum Bilirubin in ApoE Gene-Knockout Mice

Zheng Zhen-hui

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Abstract

Objective To delve into the relationship of blood-lipid to serum bilirubin in ApoE gene-knockout mice.Methods Male ApoE gene-knockout mice of twelve-month-old were selected in this study,and male C57BL/6J mice of twelve-month-old were used as controls.The levels of TG,TC,LDL-C,ApoB,T-BIL,and D-BIL in serum were determined in these mice.Results The serum levels of TG TC,LDL-C,ApoB in ApoE gene-knockout mice were significantly higher than those in C57BL/6J mice(P0.01),and the serum level of D-BIL in ApoE gene-knockout mice was significantly lower than that in C57BL/6J mice(P0.01).Conclusion Blood-lipid of the mice with atherosclerosis was correlated with serum bilirubin.

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What this paper is about

Objective To delve into the relationship of blood-lipid to serum bilirubin in ApoE gene-knockout mice.Methods Male ApoE gene-knockout mice of twelve-month-old were selected in this study,and male C57BL/6J mice of twelve-month-old were used as controls.The levels of TG,TC,LDL-C,ApoB,T-BIL,and D-BIL in serum were determined in these mice.Results The serum levels of TG TC,LDL-C,ApoB in ApoE gene-knockout mice were significantly higher than those in C57BL/6J mice(P0.01),and the serum level of D-BIL in ApoE gene-knockout mice was significantly lower than that in C57BL/6J mice(P0.01).Conclusion Blood-lipid of the mice with atherosclerosis was correlated with serum bilirubin.

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Available abstract

Objective To delve into the relationship of blood-lipid to serum bilirubin in ApoE gene-knockout mice.Methods Male ApoE gene-knockout mice of twelve-month-old were selected in this study,and male C57BL/6J mice of twelve-month-old were used as controls.The levels of TG,TC,LDL-C,ApoB,T-BIL,and D-BIL in serum were determined in these mice.Results The serum levels of TG TC,LDL-C,ApoB in ApoE gene-knockout mice were significantly higher than those in C57BL/6J mice(P0.01),and the serum level of D-BIL in ApoE gene-knockout mice was significantly lower than that in C57BL/6J mice(P0.01).Conclusion Blood-lipid of the mice with atherosclerosis was correlated with serum bilirubin.

Key concepts: Apolipoprotein E, Knockout mouse, Internal medicine, Endocrinology, Gene knockout, Apolipoprotein B, Bilirubin, Gene

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Relationship Blood-Lipid to Serum Bilirubin in ApoE Gene-Knockout Mice — Research Paper | ScholarLens