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2011•China Medical HeraldRequires access

Synthesis of 3,4,5-trimethoxylbenzyl chloride by orthogonal design

Wenbing Sheng

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Abstract

Objective: To study a good method of synthesize 3,4,5-trimethoxylbenzyl chloride.Methods: Used THF as solvent and 3,4,5-trimethoxylbenzene carbonic acid as the raw material,the 3,4,5-trimethoxylbenzyl chloride was prepared by an reduction action in ZnCl2/NaBH4 system,the acid translated into 3,4,5-trimethoxylbenzalcohol,and then by chlorination,the alcohol changed into 3,4,5-trimethoxylbenzyl chloride.Results: The target production was determined by IR and 1H-NMR spectrum.Conclusion: The 3,4,5-trimethoxylbenzyl chloride can be get by this process with high yield in mild condition.

About this research paper

What this paper is about

Objective: To study a good method of synthesize 3,4,5-trimethoxylbenzyl chloride.Methods: Used THF as solvent and 3,4,5-trimethoxylbenzene carbonic acid as the raw material,the 3,4,5-trimethoxylbenzyl chloride was prepared by an reduction action in ZnCl2/NaBH4 system,the acid translated into 3,4,5-trimethoxylbenzalcohol,and then by chlorination,the alcohol changed into 3,4,5-trimethoxylbenzyl chloride.Results: The target production was determined by IR and 1H-NMR spectrum.Conclusion: The 3,4,5-trimethoxylbenzyl chloride can be get by this process with high yield in mild condition.

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Available abstract

Objective: To study a good method of synthesize 3,4,5-trimethoxylbenzyl chloride.Methods: Used THF as solvent and 3,4,5-trimethoxylbenzene carbonic acid as the raw material,the 3,4,5-trimethoxylbenzyl chloride was prepared by an reduction action in ZnCl2/NaBH4 system,the acid translated into 3,4,5-trimethoxylbenzalcohol,and then by chlorination,the alcohol changed into 3,4,5-trimethoxylbenzyl chloride.Results: The target production was determined by IR and 1H-NMR spectrum.Conclusion: The 3,4,5-trimethoxylbenzyl chloride can be get by this process with high yield in mild condition.

Key concepts: Medicine, Chloride, Yield (engineering), Raw material, Alcohol, Solvent, Nuclear chemistry, Organic chemistry

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