Optimum synthesis of acetylferuloyl chloride by orthogonal design

Objective To optimise the process of acetylferuloyl chloride.Methods Using vanillin and acetic anhydride etc as raw materials,to synthesize acetyl-ferulic acid through Perkin reaction,finally acetylferuloyl chloride was synthesized.The main factors influenced yield of synthesis acetylferuloyl chloride and acetylferulic acid were evaluated,within synthesis acetylferuloyl chloride such as reaction time,reaction temperature and ratio of acetyl-ferulic acid and SOCl_2 and within synthesis acetylferulic acid such as reaction time,the quantity of PEG-400 and material-ratio,by the orthogonal experimental design of L_9(34)orthogonal design.Results The optimization terms of the process of the former were A_1B_2C_1,and the latter were A_1B_2C_2,the total yield reached 65%.Conclusion The best process could improve efficiency,shorten the reaction time,the experimental method was suitable for industrial production of acetylferuloyl chloride.