Primary central nervous system lymphoma:a report of 2 cases with clinicopathologic analysis and literature review

Purpose To explore the clinical characteristics,pathological features,therapy and prognosis of primary central nervous system lymphoma(PCNSL).Methods Report of 2 cases PCNSL and relevant literatures were reviewed.Results Two cases with PCNSL were HIV negative,one with anaplastic large cell lymphoma-T cell origin,the other with diffuse large B-cell lymphoma.Clinical presentations of PCNSL were an increased intracranial pressure and focal neurologic deficits with no specific imaging examination.B-cell lymphoma is the predominant subtype(87.5～98%).High-dose methotrexate-based chemotherapy with whole brain radiotherapy is efficient for PCNSL.Conclusions PCNSL is an aggressive disease with a poor prognosis and difficult to diagnose before operation.The pathological examination might be the only reliable method to confirm PCNSL.