Optimization of Ethanol Extraction Process of Jinshao Capsules by Orthogonal Design

Objective To optimize the ethanol extraction process of Jinshao Capsules.Methods The content of berberine hydrochloride and the yield of extract were used for the indicators,and the orthogonal experiment was adopted for the optimization.Results The concentration of the ethanol had stronger effect on the extraction than the other two factors of ethanol volume and extraction times.The optimized technology was A3B2C1.In other words,the optimized technology was as follows: reflowing extraction twice with 70% ethanol which was eight times first and then six times as much as the medical material,one hour each time.Conclusion This process has higher extraction rate of berberine hydrochloride and has good stability,which is simple and economic,and is suitable for industrial production.