Expression and Clinical Significance of Matrix Metalloproteinase 7 and E-cadherin in Carcinoma of Endometrium

Objective To study the expression and clinical significance of Matrix metalloproteinase 7(MMP-7) and E-cadherin(E-CAD) in carcinoma of endometrium tissue.Methods Tissue specimens of the endometria were respectively collected from 72 patients with carcinoma of endometrium,64 patients with precancertissue and 80 normal women. Immunohistochemical analysis was employed to detect the expression of MMP-7 and E-CAD in these specimens.Results The expression rate of MMP-7 was significantly higher in carcinoma of endometrium group and precancertissue group than those in normal group. In normal group and precancertissue group,the expression rate of E-CAD was significantly higher than those in carcinoma of endometrium group. MMP-7 expression amplified significantly when clinical disease period raised,tissue classification decreased and lymph node transferred. The expression of E-CAD was found antithesis in these situation and had inverse correlate with MMP-7.Conclusion MMP-7 plays an important role in carcinoma of endometrium beginning. MMP-7 increment and E-CAD abatement are the important promoting factors in the infiltration and transition of carcinoma of endometrium.