2007•Journal of Beijing University of Traditional Chinese MedicineRequires access
Effect of Weikang Capsules on expression of apoptosis-related proteins of gastric mucosa in rats with chronic atrophic gastritis of precancerous lesion
Tian De-lu
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Abstract
Objective To investigate the pathogenesis of chronic atrophic gastritis of precancerous lesion and therapeutic mechanism of Weikang Capsules on the base of expression of apoptosis-related proteins.Methods The model of chronic atrophic gastritis of precancerous lesion was established by using a synthetic method.The effect of Weikang Capsules on expression of apoptosis-related proteins Bcl-2 and Bax of gastric mucosa in rats with chronic atrophic gastritis of precancerous lesion was observed by using immunohistochemistry method.Results In the gastric mucosa in rats with chronic atrophic gastritis of precancerous lesion,the positive expression of Bcl-2 protein was increased significantly than that in the normal group(P0.01),while decreased in the low-dose and high-dose of Weikang Capsules groups with a significant difference compared with that of the spontaneous recovery group(P0.01).The positive expression of Bax protein was increased in normal group,while significantly decreased in the precancerous lesion of those model group and spontaneous recovery group(P0.01).Especially in the dysplasia area,the expression distinctively decreased in degrees with the development of dysplasia.The positive expression of Bax protein was increased in the low-dose and high-dose of Weikang Capsules groups compared with the spontaneous recovery group(P0.01).Conclusion The abnormal expressions of Bcl-2 and Bax proterin exist in the epithelial cell of gastric mucosa in rats with chronic atrophic gastritis of precancerous lesion.It suggests that up-regulated expression of Bcl-2 protein and down-regulated expression of Bax protein maybe the mechanism of Weikang Capsules on curing chronic atrophic gastritis of precancerous lesion.