ScholarLens Back to search
2012•Xiandai shengwu yixue jinzhanRequires access

A Comparison Analysis between the Expressions of Serum MiR-200a and AFP in Liver Cirrhosis and Liver Cancer Patients

Haimin Li

Open publisher page 0 citations

Abstract

Objective:This study aimed to analyze the expression levels of serum microRNA-200a(miR-200a) and AFP in liver cirrhosis and liver cancer patients,and to explore whether miR-200a could be a novel biomarker of liver cancer.Methods: Patients with normal liver,liver cirrhosis and liver cancer in clinic were included in this study.Blood samples of the patients were collected for analysis.Real time quantitative PCR technique was used to measure the expression level of serum miR-200a.The AFP expression was got from clinical data.Results: Comparing with normal liver patients,miR-200a presented lower expressions in liver cirrhosis patients and liver cancer patients(P0.05),while AFP presented higher expressions only in liver cancer patients(P0.05).Conclusion: Data indicated that MiR-200a played an important role in liver cancer development and had diagnostic value for indicating liver cirrhosis and liver cancer.

About this research paper

What this paper is about

Objective:This study aimed to analyze the expression levels of serum microRNA-200a(miR-200a) and AFP in liver cirrhosis and liver cancer patients,and to explore whether miR-200a could be a novel biomarker of liver cancer.Methods: Patients with normal liver,liver cirrhosis and liver cancer in clinic were included in this study.Blood samples of the patients were collected for analysis.Real time quantitative PCR technique was used to measure the expression level of serum miR-200a.The AFP expression was got from clinical data.Results: Comparing with normal liver patients,miR-200a presented lower expressions in liver cirrhosis patients and liver cancer patients(P0.05),while AFP presented higher expressions only in liver cancer patients(P0.05).Conclusion: Data indicated that MiR-200a played an important role in liver cancer development and had diagnostic value for indicating liver cirrhosis and liver cancer.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:This study aimed to analyze the expression levels of serum microRNA-200a(miR-200a) and AFP in liver cirrhosis and liver cancer patients,and to explore whether miR-200a could be a novel biomarker of liver cancer.Methods: Patients with normal liver,liver cirrhosis and liver cancer in clinic were included in this study.Blood samples of the patients were collected for analysis.Real time quantitative PCR technique was used to measure the expression level of serum miR-200a.The AFP expression was got from clinical data.Results: Comparing with normal liver patients,miR-200a presented lower expressions in liver cirrhosis patients and liver cancer patients(P0.05),while AFP presented higher expressions only in liver cancer patients(P0.05).Conclusion: Data indicated that MiR-200a played an important role in liver cancer development and had diagnostic value for indicating liver cirrhosis and liver cancer.

Key concepts: Cirrhosis, Liver cancer, Medicine, Internal medicine, Gastroenterology, Biomarker, microRNA, Cancer

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
A Comparison Analysis between the Expressions of Serum MiR-200a and AFP in Liver Cirrhosis and Liver Cancer Patients — Research Paper | ScholarLens