2005•Clinical Medical Journal of ChinaRequires access
Reserch on Serum HBV DNA Level and HBeAg in Evaluating Liver Damage of Patients with Chronic Hepatitis B
Shen Xi-zhong
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Abstract
Objective: To investigate the correlation between serum HBeAg, HBV DNA levels and hepatic histopathologic impairment which consisted of the grade of liver inflammation and the stage of the liver fibrosis in patients with chronic hepatitis B. Methods: Liver puncture for histopathologic examinations were performed in 167 patients suffering from chronic hepatitis B. The quantitative analysis of serum HBV DNA and hepatitis B markers were also evaluated, Results: Neither the grades of liver inflammation nor the stages of liver fibrosis were correlated with serum HBeAg expression. No correlations were found between serum HBV DNA levels and the grade of liver inflammation. Only HBV DNA levels were different from stage 0 to stage 4. Conclusion: There were no significant correlation between HBeAg, HBV DNA levels and the hepatic histopathologic impairment which included the grade of liver inflammation and the stage of liver fibrosis. The expression of HBeAg and the quantitative analysis of HBV DNA could not be used to evaluate liver histopathologic impairment in patients with chronic hepatitis B.