Significance of combined detection of tumor markers CA19-9, CA242, CEA and CA125 in the diagnosis of pancreatic carcinoma

Objective To explore the clinical diagnostic value of combined detection of tumor markers CA19-9, CA242, CEA and CA125 of pancreatic carcinoma. Methods Detection of serum tumor markers CA19-9, CA242, CEA and CA125 was carried out in 48 patients with pancreatic carcinoma and 48 healthy volunteers. Results The levels of tumor markers in pancreatic carcinoma group were significantly higher than those in the normal control group (P0.01). The sensitivity of CA19-9, CA242, CEA and CA125 in patients with pancreatic carcinomas was 79.2%, 54.2%, 50.0% and 35.4%, respectively. The specificity of CA19-9, CA242, CEA and CA125 was 87.5%, 89.6%, 79.2% and 70.8%, respectively. The sensitivity and specificity of combined detection were 93.8% and 100%. Conclusion The sensitivity and specificity of combined detec- tion of CA199, CA242, CEA and CA125 are higher than that of the single detection, and can improve the detection rate of pancreatic carcinoma.