The Preventive Effect of XSZII on Pregnancy-Induced Hypertension in Rats

Objective: To study the hypotensive and preventive effects of XSZⅡ on pregnancy-induced hypertension in rat model established by L-NAME. Methods: Pregnancy rats were assigned to 5 groups according to the sequence of pregnancy including normal pregnancy rats (A group, n = 6, PO distilled water 10 mL/kg from E10),hypertension control rats (B group, n = 10, PO distilled water 10 mL/kg from E10),Epsom salt control rats (C group,n = 8, ip Epsom salt 100 mg/kg from E14),XSZⅡ 42 g/kg group(D group,n = 10, PO XSZⅡ 42 g/kg from 10) and XSZⅡ 21 g/kg group(E group,n = 9, PO XSZⅡ 21 g/kg from E10). Pregnancy rats were injected 7 mg/kg L-NAME i.v. on the E14 once a day for 4 days except for rats of A group. The values of tail arterial blood pressure, urine protein, placental weight, fetal death rate and birth defects rate were measured in rats. Results: There were different significances in systolic blood pressure, diastolic blood pressure and mean arterial pressure between D and B group(P 0.01). The systolic blood pressure was significantly decreased in E group compared with that of B group (P 0.05). There was no significant improvement in urine protein in rats treated by XSZⅡ. The still birth rate was significant lower in E group than that of B group (P 0.01). The abnormal embryo rate was also significant lower in rats of E group than that of control group (P 0.01). Conclusion: For pregnancy-induced hypertension, XSZⅡ can effectively reduce the blood pressure and promote blood supply to the placenta and fetal rat development.