2003•Acta Medicinae SinicaRequires access

Effect of RG50864 on Pulmonary Artery Smooth Muscle Cell Proliferation of Platelet Derived Growth Factor Induced

Chang Wang

Abstract

Objective:To explore the effect of tyrosine protein kinase(TPK) inhibitor RG50864 on Pulmonary artery smooth muscle cell(PASMC) proliferation of platelet derived growth factor(PDGF) induced.Methods:By primary culture of calf PASMC,the effect of PDGF induced PASMC proliferation was analysed using MTT colorimetry,Giemsa staining and cell count.Results:As compared with control group,PDGF induced PASMC proliferation was significantly inhibited by RG50864 groups in a dose dependent manner.Conclusion:RG50864 could block PDGF induced PASMC proliferations.

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Key concepts: Platelet-derived growth factor receptor, Platelet-derived growth factor, Growth factor, Giemsa stain, Cell growth, Pulmonary artery, Cell, Staining