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Preventive effect of extraction from Bidens pilosa L on experimental liver injury in mice

Yu Yanhong

Open publisher page 1 citations

Abstract

Objective To observe the preventive effect of extraction from Bidens pilosa L on experimental liver injury in mice.Methods Fifty mice were divided into the normal group,model group,the bifendate group [150 mg/(kg·d)],the low-dose[10 g/(kg·d)] and the high-dose[20 g/(kg·d)] Bidens pilosa L Except normal group,the mice models of experimental liver injury in the other groups were set up by carbon tetrachloride(CCl_4).The serum ALT and AST,liver MDA content,activity of GSH-Px were measured to evaluate the protective effect of extraction from Bidens pilosa L on experimental liver injury in mice.Results The extraction from Bidens pilosa L significantly decreased serum ALT,AST and liver MDA content,and elevated activity of GSH-Px induced by CCl_4. Conclusion The extraction from Bidens pilosa L.shows preventive effect on liver injury induced by CCl_4.

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Objective To observe the preventive effect of extraction from Bidens pilosa L on experimental liver injury in mice.Methods Fifty mice were divided into the normal group,model group,the bifendate group [150 mg/(kg·d)],the low-dose[10 g/(kg·d)] and the high-dose[20 g/(kg·d)] Bidens pilosa L Except normal group,the mice models of experimental liver injury in the other groups were set up by carbon tetrachloride(CCl_4).The serum ALT and AST,liver MDA content,activity of GSH-Px were measured to evaluate the protective effect of extraction from Bidens pilosa L on experimental liver injury in mice.Results The extraction from Bidens pilosa L significantly decreased serum ALT,AST and liver MDA content,and elevated activity of GSH-Px induced by CCl_4. Conclusion The extraction from Bidens pilosa L.shows preventive effect on liver injury induced by CCl_4.

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Available abstract

Objective To observe the preventive effect of extraction from Bidens pilosa L on experimental liver injury in mice.Methods Fifty mice were divided into the normal group,model group,the bifendate group [150 mg/(kg·d)],the low-dose[10 g/(kg·d)] and the high-dose[20 g/(kg·d)] Bidens pilosa L Except normal group,the mice models of experimental liver injury in the other groups were set up by carbon tetrachloride(CCl_4).The serum ALT and AST,liver MDA content,activity of GSH-Px were measured to evaluate the protective effect of extraction from Bidens pilosa L on experimental liver injury in mice.Results The extraction from Bidens pilosa L significantly decreased serum ALT,AST and liver MDA content,and elevated activity of GSH-Px induced by CCl_4. Conclusion The extraction from Bidens pilosa L.shows preventive effect on liver injury induced by CCl_4.

Key concepts: Bidens pilosa, Carbon tetrachloride, Liver injury, Extraction (chemistry), Traditional medicine, Chemistry, Glutathione, Normal group

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