Esomeprazole and Mosapride in the treatment of gastroesophageal reflux disease

Objective To investigate the effect of Esomeprazo1e and Mosapride in the treatment of gastroesophageal reflux disease(GERD).Methods Eighty patients with GERD,based on a randomized double-blind method,was divided into two groups.The treatment group of 40 patients was given Esomeprazole 40 mg/day,Mosapride 5 mg,orally taken 3 times a day.Control group of 40 patients orally took Esomeprazole 40 mg/day.Six weeks after treatment,stomach heartburn,reflux,and anti-acid,non-cardiac chest pain and other symptoms of mitigation were observed,and on the sixth week,gastroscopy and esophagitis cure rate were reviewed.Results The treatment group after 6 weeks has the recovery rate of 95%,the control group 80%.Great difference appeared between the two groups(P0.01).The treatment group after 6 weeks has the recovery rate of 70% in A,B,C,D′s levels of esophagitis and the overall rate of 90%.The difference is significant(P0.01).Conclusion Esomeprazole combined with Mosapride in the treatment of gastroesophageal reflux disease is an effective program.