2008•Shandong yiyaoRequires access
Relationship between CD_4~+CD_(25)~+ T lymphocytes of peripheral blood and lung cancer
Yi-Qing Qu
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Abstract
Objective To evaluate the correlation between CD+4CD+25 regulatory T lymphocytes and lung cancer.Methods Peripheral blood was obtained from 68 patients with lung cancer and 30 healthy persons.The percentages of CD+4CD+25 cells in total CD+4 cells,the expressive rates of CD+4,CD+56 and the ratio of CD+4/CD+8 were detected by flowe cytometry,the content of TGF-β、IL-10 and IFN-γ was detected by enzyme-labeled immunosorbent assay.Results The percent of CD+4CD+25 regulatory T lymphocytes in peripheral blood of lung cancer was higher than that of healthy volunteers(P0.05).The level of TGF-β,IL-10 in peripheral blood of lung cancer was higher than that of healthy volunteers(P0.05).The level of IFN-γ in the lung cancer was lower than that of the healthy volunteers(P0.05).Conclusions The relative increase in CD+4CD+25regulatory T cells may be related to immunosuppression and tumor progression in patients with lung cancer.