Expressions of CD_3~+,CD_4~+,CD_8~+ and CD_(44)~+ in Patients with Non-small Cell Lung Cancer

Objective To study the expressions of CD+3,CD+4,CD+8 and CD+44 in peripheral blood lymphocyte in patients with non-small cell lung cancer and investigate the clinical values.Methods CD+3,CD+4,CD+8 and CD+44 expressions in peripheral blood lymphocyte in 65 patients with non-small cell lung cancer were detected by the method of immune-flow-cytometry,22 healthy persons as controls.The results were analyzed.Results CD+3,CD+4,CD+8 and CD+44 contents were different between patients with non-small cell lung cancer and healthy persons(P0.05).Levels of CD+3,CD+4,CD+8 and CD+44 in non-small cell lung cancer group were respectively 58.83±10.88%,34.89±6.45%,23.91±4.42% and 55.45±4.35%,and levels of CD+3,CD+4,CD+8 and CD+44 in normal controls were respectively 48.07±10.33%,30.93±6.68%,17.13±3.37% and 62.85±7.56%;There was no distinct difference between scale cell cancer and adenocarcinoma in CD+44 expressions(P0.05).Levels of CD+44 in scale cell cancer and adenocarcinoma were respectively 64.43±6.76% and 64.43±6.76%.Conclusion Patients with lung cancer have a significantly lower cellular immunity dysfunction and anticancer ability than those in normal persons.There are no obvious relations in the expression of CD+44 in different pathological types of non-small cell lung cancer.