Pharmacogenomics of Drugs Acting on Hypertension

Genetics can influence the pharmacokinetics and pharmacodynamics of drugs at different levels. This review focus on the progress of polymorphisms in multifactorial diseases (polymorphisms and the efficacy of antihypertensive treatment and 4 candidate gene studies ( renin-angiotensin system genes, α-adducin gene,genes associated with salt-sensitive hypertension and Gsα gene). Through the identification of genetic, markers of drug response and the evaluation of their genetic background, which will help us to achieve a better way of antihypertensive therapy to individual patients and getting a better control of blood pressure in the population.