The Changes and Significance of Plasma Intercellular Adhesion Molecule and Transforming Growth Factor in Patients with Acute Coronary Syndrome

Objective: To investigate the changes and significance of plasma intercellular adhesion molecule 1 (sICAM 1) and transforming growth factor β (TGF β) in patients with acute coronary syndrome (ACS). Methods: 5 ml blood was drawn from cubital vein in 45 patients with ACS within the 1st hour of hospitalization. sICAM 1 and TGF β were measured while creatine kinase(CK), MB isoenzyme of creatine kinase(CK MB) and lactate dehydrogenase(LDH) were detected at same time. Healthy people were regarded as control group. Results: Plasma sICAM 1 level was increased significantly: unstable angina pectoris group (UAP) was 359.08±35.12 , non Q wave acute myocardial infarction group (NQMI) was 495.34±49.16 , Q wave acute myocardial infarction group (AMI) was 583.51±54.27 . As compared with the control group ( 253.51±38.43 ), there was a significant difference ( P 0.001 ). Plasma TGF β level was decreased significantly (UAP 46.72±10.15 , NQMI 41.69±9.08 , AMI 36.72±8.79 ) in comparison with control group ( 62.10±14.46 ) ( P 0.001 ). There was a significant negative correlation between sICAM 1 and TGF β( P 0.01 ), and significant positive correlation between sICAM 1 and CK, CK MB, LDH ( P 0.01 ). Conclusion: The changes of sICAM 1 and TGF β levels may reflect the immunological and inflammatory status of the patients with ACS. It might be a new way to prevent and treat ACS with suppression of the inflammatory cytokine and improve the action of anti inflammatory cytokines.