2008•Zhongguo zhongyiyao xinxi zazhiRequires access
Effects of Buqi Huoxue Decoction on Levels of β-AP,TGF-α and IGF-II in Rats of Multi-Factor AD Model
Jiang Guohua
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Abstract
Objective To observe the effects of Buqi Huoxue Decoction on levels of β-AP,TGF-α and IGF-Ⅱ in rats of multi-factor AD model and investigate the mechanism of treating AD with Buqi Huoxue Decoction. Method Multi-factor AD Model was established with D-galactose and SCOP by abdominal injection,AlCl3 by perfusion and QA by hippocampus injection. All rats were randomly divided into five groups:A (control group),B (pseudo injuried group),C (model group),D (Buqi Huoxue Decoction group) and E (hydergine group). Group D was treated by Buqi Huoxue Decoction and group E was treated by hydergine. β-AP,TGF-α and IGF-Ⅱ level in the blood of AD model were detected by radio-immuno-assay after treatment course. Results β-AP,TGF-α and IGF-Ⅱ level in the blood of group D and E were decreased significantly compared with group C after treatment. Conclusion Buqi Huoxue Decoction could decrease the high level of β-AP,TGF-α and IGF-II in the blood of multi-factor AD model,so as to achieve the therapeutic effect.