Detection of Peripheral Blood T Cell and TGF-β in SLE

Objective To investigate the expression of peripheral blood CD4+CD25+ FOXP3+T cells and the TGF-β level in SLE and analyze their role in the pathogenesis of SLE. Methods Peripheral anticoagulant venous blood was collected from SLE patients and healthy controls and the peripheral blood CD4+CD25+FOXP3+ T cells were detected by flow cytometry and the peripheral blood TGF-β level was assayed by ELISA. Results The percentage of the CD4+CD25+FOXP3+ T cell was lower in the SLE patients than that in the healthy control group,and the TGF-β level in SLE was significantly higher than that in the healthy control group(P0.05). Conclusion The reduction in the CD4+CD25+FOXP3+T cells and the lowered TGF-β may play an important role in the pathogenesis of SLE.