The effects of orthodontic force on the expression of IL-6 and the alveolar bone remodeling in rats

Objective: To investigate the expression and distribution of IL-6 in periodontal tissues and the change of the alveolar bone of rats during orthodontic tooth movement,and to study the effects of orthodontic force on the periodontal tissue remodeling.Methods: 50 gram orthodontic force was loaded on the left first maxillary molars of 25 rats in experimental group.Immunohistochemistry and histomorphometric analysis were performed to measure the expression of IL-6 and the loss of alveolar bone at 0,1,3,5,7 and 10 days after the application of orthodontic force.Results: The expression of IL-6 was observed to reach maximum level on day 3 and to decline thereafter in experimental group.No obvious alveolar bone loss was detected in the mesial side of the first molars.Conclusion: Although orthodontic force can evoke the local inflammatory response of periodontal tissue and the expression of pro-inflammation cytokines such as IL-6,it can not cause severe periodontal destruction and alveolar bone loss.