2005•Zhongguo mianyixue zazhiRequires access

Changes of BDNF level expression in Hippocampal and Habenular nucles in experimental depression rats

Ren Ai

Abstract

Objective:To observe the change of BDNF level expression in experimental in hippocampal and habenular nucles in experimental depression rats.Methods:The depression model of rats was established by chronic unpredictable mild stress. Openfield test was performed to detect the behavior of rats. Immunohistochemistry was used to observe the changes of BDNF level.Results:Compared to the control group,the number of depressed animals was much less than that of normal animals.Conclusion:The level of BDNF decrease significantly in experimental depressive model of rats.

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Available abstract

Key concepts: Hippocampal formation, Internal medicine, Depression (economics), Endocrinology, Immunohistochemistry, Hippocampus, Behavioural despair test, Brain-derived neurotrophic factor