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The impact of chronic stress on the behaviors and the expression of brain-derived neurotrophic factor in the hippocampus of rats

Peng Miao

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Abstract

ObjectiveTo study the changes of behaviors , structure and expression of BDNF in hippocampus of rats under the conditions of chronic unpredictable stress and separation. Methods After 21-daystress on the stress group, the behaviors were observed and the levels of BDNF in hippocampus were detected by ABC method for all rats. ResultsAfter chronic stress, depression-like behaviors can be observed and the levels of BDNF decreased significantly in stress group (P0.01). The high levels of BDNF can be observed in DG zone (optical density was 40.53±2.62,sectional area was 2.013±0.074) and CA3 zone (optical density was 39.09±3.19,sectional area was 1.910±0.056) in control group. ConclusionsThe depressive model can be established steadily by chronic unpredictable stress with separation. Chronic stress can decrease the expression of BDNF in hippocampusof rats. DG zone and BDNF play an important role in hippocampal plasticity.

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ObjectiveTo study the changes of behaviors , structure and expression of BDNF in hippocampus of rats under the conditions of chronic unpredictable stress and separation. Methods After 21-daystress on the stress group, the behaviors were observed and the levels of BDNF in hippocampus were detected by ABC method for all rats. ResultsAfter chronic stress, depression-like behaviors can be observed and the levels of BDNF decreased significantly in stress group (P0.01). The high levels of BDNF can be observed in DG zone (optical density was 40.53±2.62,sectional area was 2.013±0.074) and CA3 zone (optical density was 39.09±3.19,sectional area was 1.910±0.056) in control group. ConclusionsThe depressive model can be established steadily by chronic unpredictable stress with separation. Chronic stress can decrease the expression of BDNF in hippocampusof rats. DG zone and BDNF play an important role in hippocampal plasticity.

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Available abstract

ObjectiveTo study the changes of behaviors , structure and expression of BDNF in hippocampus of rats under the conditions of chronic unpredictable stress and separation. Methods After 21-daystress on the stress group, the behaviors were observed and the levels of BDNF in hippocampus were detected by ABC method for all rats. ResultsAfter chronic stress, depression-like behaviors can be observed and the levels of BDNF decreased significantly in stress group (P0.01). The high levels of BDNF can be observed in DG zone (optical density was 40.53±2.62,sectional area was 2.013±0.074) and CA3 zone (optical density was 39.09±3.19,sectional area was 1.910±0.056) in control group. ConclusionsThe depressive model can be established steadily by chronic unpredictable stress with separation. Chronic stress can decrease the expression of BDNF in hippocampusof rats. DG zone and BDNF play an important role in hippocampal plasticity.

Key concepts: Hippocampus, Neurotrophic factors, Chronic stress, Hippocampal formation, Brain-derived neurotrophic factor, Endocrinology, Internal medicine, Neuroplasticity

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